The history of SeRum dates back to the 19th century, when the Panama Canal was being built. Due to the harsh working conditions and the outbreak of malaria, many Cubans and people living in the Caribbean died. Cuban women added dried fruit and spices to their old Panamanian spirits to create a type of energy drink that was supposed to give men strength. Later, these spirits were also administered for snakebites and malaria, as they were believed to have healing properties; hence the name 'SeRum'. SeRum Ancon was named after the American cargo and passenger ship that officially became the first ship to cross the Panama Canal in 1914. From that day on, SeRum Ancon was drunk on deck to toast a safe journey.

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